abstract：BACKGROUND:Bacterial infections in the genital tract frequently result in morbidity through a variety of inflammation based symptoms. One component of the bacteria that may trigger host inflammatory response is their DNA. CpG motifs in this DNA are known targets for Toll-like receptor 9 (TLR9), which is a pathogen-reco...

journal_title：BMC infectious diseases

authors： Singer M,de Waaij DJ,Morré SA,Ouburg S

更新日期：2015-07-16 00:00:00

abstract：BACKGROUND:Periodontal diseases may affect local and systemic inflammation, and reactive oxygen species (ROS) levels. This systemic health burden could compromise the outcome of pregnancy in expectant mothers. The aim of the present study was to evaluate oxidative stress markers, including glutathione peroxidase (GPx),...

journal_title：BMC infectious diseases

authors： Gümüş P,Emingil G,Öztürk VÖ,Belibasakis GN,Bostanci N

更新日期：2015-07-08 00:00:00

abstract：BACKGROUND:Human T-lymphotropic virus type 1 (HTLV-1), a retrovirus, is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia/lymphoma (ATLL). The reported association with pulmonary disease such as bronchiectasis is less certain. METHODS:A retrospective ...

journal_title：BMC infectious diseases

authors： Honarbakhsh S,Taylor GP

更新日期：2015-07-06 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) markedly reduces HIV transmission, and testing and treatment programs have been advocated as a method for decreasing transmission at the population level. Little is known, however, about the extent to which sexually transmitted infections (STIs), which increase the HIV infectious...

journal_title：BMC infectious diseases

authors： Champredon D,Bellan SE,Delva W,Hunt S,Shi CF,Smieja M,Dushoff J

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:The aim of this study was to characterize the spread of carbapenemase-producing Klebsiella pneumoniae (CPKP) in a tertiary level hospital using ongoing active surveillance with rectal swab cultures. Furthermore, this study analyzed the presence of CPKP in the clinical samples (CS) of a single patient as well...

journal_title：BMC infectious diseases

authors： Parisi SG,Bartolini A,Santacatterina E,Castellani E,Ghirardo R,Berto A,Franchin E,Menegotto N,De Canale E,Tommasini T,Rinaldi R,Basso M,Stefani S,Palù G

更新日期：2015-06-27 00:00:00

abstract：BACKGROUND:The most common cause of implant failure is aseptic loosening (AL), followed by prosthetic joint infection (PJI). This study evaluates the incidence of PJI among patients operated with suspected AL and whether the diagnosis of PJI was predictive of subsequent implant failure including re-infection, at 2 year...

journal_title：BMC infectious diseases

authors： Fernandez-Sampedro M,Salas-Venero C,Fariñas-Álvarez C,Sumillera M,Pérez-Carro L,Fakkas-Fernandez M,Gómez-Román J,Martínez-Martínez L,Fariñas MC

更新日期：2015-06-18 00:00:00

abstract：BACKGROUND:Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severely malnourished children are systematically excluded. Few studies have assessed the efficacy of chloroquine, sulfadoxine-pyr...

journal_title：BMC infectious diseases

authors： Denoeud-Ndam L,Dicko A,Baudin E,Guindo O,Grandesso F,Sagara I,Lasry E,Palma PP,Parra AM,Stepniewska K,Djimde AA,Barnes KI,Doumbo OK,Etard JF

更新日期：2015-06-12 00:00:00

abstract：BACKGROUND:This study presents an analysis of 1,491 serogroup 23 and 762 serogroup 15 isolates from invasive pneumococcal disease (IPD) in children and adults before and after the general recommendation for childhood pneumococcal conjugate vaccination in Germany in July 2006. Vaccination formulations used were PCV7 (fr...

journal_title：BMC infectious diseases

authors： van der Linden M,Perniciaro S,Imöhl M

更新日期：2015-05-05 00:00:00

abstract：BACKGROUND:Comparison of antimicrobial de-escalation rates between healthcare settings is problematic. To objectively and electronically measure de-escalation a method based upon the spectrum of antimicrobial regimens administered (i.e., spectrum score) was developed. METHODS:A Delphi process was used to develop appli...

journal_title：BMC infectious diseases

authors： Madaras-Kelly K,Jones M,Remington R,Caplinger C,Huttner B,Samore M

更新日期：2015-04-25 00:00:00

abstract：BACKGROUND:Human rotavirus A (human RV-A) is the most common cause of viral gastroenteritis in infants. The objective of the study was to characterize the G and P genotypes among clinical rotavirus isolates from children with acute diarrhea admitted to a tertiary care hospital in Riyadh, Saudi Arabia. METHODS:From 201...

journal_title：BMC infectious diseases

authors： Aly M,Al Khairy A,Al Johani S,Balkhy H

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:Clostridium difficile infection (CDI), a complication of antibiotic-induced injury to the gut microbiome, is a prevalent and dangerous cause of infectious diarrhea. Antimicrobial therapy for CDI is typically effective for acute symptoms, but up to one third of patients later experience recurrent CDI. Fecal-d...

journal_title：BMC infectious diseases

authors： Hirsch BE,Saraiya N,Poeth K,Schwartz RM,Epstein ME,Honig G

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:The objective of this study was to explore effects of khat (Catha edulis) on outcome of rodent malaria infection and its anti-plasmodial activities on Plasmodium berghei ANKA (PbA). METHODS:Female Swiss albino mice were orally treated with crude khat (Catha edulis) extracts (100, 200 and 300 mg/kg) on a dai...

journal_title：BMC infectious diseases

authors： Ketema T,Yohannes M,Alemayehu E,Ambelu A

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:The risk of life-threatening and invasive infections with encapsulated bacteria is increased in patients with hyposplenia or asplenia. We report a case of recurrent invasive pneumococcal meningitis in a woman with previous unknown hyposplenia. She was vaccinated after the first episode of meningitis and deve...

journal_title：BMC infectious diseases

authors： Ballegaard VC,Schejbel L,Hoffmann S,Kantsø B,Fischer CP

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:The role of single nucleotide polymorphisms (SNPs) of interleukin (IL)-28B in predicting therapeutic response of pegylated interferon (peg-IFN) plus ribavirin (PR) for genotype 1 infected chronic hepatitis C patients with advanced fibrosis (AF) is limited. The aim of this study is to assess its role in predi...

journal_title：BMC infectious diseases

authors： Hu CC,Lin CL,Chang LC,Chien CH,Chen LW,Liu CJ,Chien RN

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:Elderly people are at increased risk for severe influenza illness and constitute therefore a major target-group for seasonal influenza vaccination in most industrialized countries. The aim of this study was to estimate influenza vaccine effectiveness (VE) among individuals aged 60+ years over three seasons a...

journal_title：BMC infectious diseases

authors： Remschmidt C,Rieck T,Bödeker B,Wichmann O

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:Recently we developed and validated generic quality indicators that define 'appropriate antibiotic use' in hospitalized adults treated for a (suspected) bacterial infection. Previous studies have shown that with appropriate antibiotic use a reduction of 13% of length of hospital stay can be achieved. Our mai...

journal_title：BMC infectious diseases

authors： van Daalen FV,Prins JM,Opmeer BC,Boermeester MA,Visser CE,van Hest RM,Hulscher ME,Geerlings SE

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:We have recovered one bla(NDM-1)-harboring bacterial strain, designated as XM1570, from a sputum sample obtained from a fatal case of pneumonia in China. METHODS:Biochemical profiling, 16S rRNA sequencing and antimicrobial susceptibility testing were performed. Conjugation experiments were conducted to dete...

journal_title：BMC infectious diseases

authors： Li P,Yang C,Xie J,Liu N,Wang H,Zhang L,Wang X,Wang Y,Qiu S,Song H

更新日期：2015-03-18 00:00:00

abstract：BACKGROUND:Antibiotic resistance is a threat in developing countries (DCs) because of the high burden of bacterial disease and the presence of risk factors for its emergence and spread. This threat is of particular concern for neonates in DCs where over one-third of neonatal deaths may be attributable to severe infecti...

journal_title：BMC infectious diseases

authors： Huynh BT,Padget M,Garin B,Herindrainy P,Kermorvant-Duchemin E,Watier L,Guillemot D,Delarocque-Astagneau E

更新日期：2015-03-15 00:00:00

abstract：BACKGROUND:Hepatitis B Virus (HBV) disproportionately affects new immigrants from endemic regions such as China. Untreated infections increase health risks for liver diseases including cancer. Yet most of those infected are unaware of their disease limiting prevention and early treatment options. The purpose of this co...

journal_title：BMC infectious diseases

authors： Ma GX,Zhang GY,Zhai S,Ma X,Tan Y,Shive SE,Wang MQ

更新日期：2015-03-08 00:00:00

abstract：BACKGROUND:The present study aims to investigate the potential mechanism of linezolid-resistant Staphylococcus capitis (LRSC) isolates collected from our hospital. METHODS:The susceptibilities of 5 Staphylococcus capitis isolates displaying resistance towards linezolid were determined by E-test. Polymerase chain react...

journal_title：BMC infectious diseases

authors： Zhou W,Niu D,Cao X,Ning M,Zhang Z,Shen H,Zhang K

更新日期：2015-02-26 00:00:00

abstract：BACKGROUND:Pneumocystis pneumonia (PCP) may develop as a clinical manifestation of nosocomial pneumonia by means of either reactivation of resident P. jirovecii or de novo infection. However, there have been no studies describing the clinical characteristics of hospital-onset PCP. METHODS:A retrospective review of med...

journal_title：BMC infectious diseases

authors： Kim T,Lee SO,Hong HL,Lee JY,Kim SH,Choi SH,Kim MN,Kim YS,Woo JH,Sung H

更新日期：2015-02-26 00:00:00

abstract：BACKGROUND:The rate of vertical HIV transmission has decreased in Brazil, but regional inequalities suggest problems in implementing control measures during pregnancy and delivery. The aims of this study were to ascertain the coverage of HIV testing during prenatal care and estimate the prevalence of HIV infection duri...

journal_title：BMC infectious diseases

authors： Domingues RM,Szwarcwald CL,Souza PR Jr,Leal Mdo C

更新日期：2015-02-26 00:00:00

abstract：BACKGROUND:Dose-response assessment is one step in quantitative microbial risk assessment (QMRA). Four infectious microbes capable of causing respiratory diseases important to public health, and for which dose-response functions have not been available are: Bordetella pertussis (whooping cough), group A Streptococcus (...

journal_title：BMC infectious diseases

authors： Jones RM,Su YM

更新日期：2015-02-24 00:00:00

abstract：BACKGROUND:During weeks 32-33, 2013, 24 cases of cryptosporidiosis were notified in the city of Halle (annual mean 2008-2012: 9 cases). We investigated the outbreak to identify the source and recommend control measures, considering that between weeks 23-25 the river Saale which flows through the city centre overflowed ...

journal_title：BMC infectious diseases

authors： Gertler M,Dürr M,Renner P,Poppert S,Askar M,Breidenbach J,Frank C,Preußel K,Schielke A,Werber D,Chalmers R,Robinson G,Feuerpfeil I,Tannich E,Gröger C,Stark K,Wilking H

更新日期：2015-02-22 00:00:00

abstract：BACKGROUND:The spatial spread of H5N1 avian influenza, significant ongoing mutations, and long-term persistence of the virus in some geographic regions has had an enormous impact on the poultry industry and presents a serious threat to human health. METHODS:We applied phylogenetic analysis, geospatial techniques, and ...

journal_title：BMC infectious diseases

authors： Tian H,Cui Y,Dong L,Zhou S,Li X,Huang S,Yang R,Xu B

更新日期：2015-02-13 00:00:00

abstract：BACKGROUND:Several in vitro studies suggested the microRNA-29 (miRNA-29) family is involved in regulating HIV-1 and modulating the expression of interleukin (IL)-32, an anti-HIV-1 cytokine. METHODS:To investigate the contribution of the miRNA-29 family to HIV-1 infection in vivo, we compared miRNA-29 expression in PBM...

journal_title：BMC infectious diseases

authors： Monteleone K,Selvaggi C,Cacciotti G,Falasca F,Mezzaroma I,D'Ettorre G,Turriziani O,Vullo V,Antonelli G,Scagnolari C

更新日期：2015-02-12 00:00:00

abstract：BACKGROUND:Annual influenza vaccination of healthcare workers (HCWs) is recommended in Australia, but uptake in healthcare facilities has historically been low (approximately 50%). The objective of this study was to develop and implement a dedicated campaign to improve uptake of staff influenza annual vaccination at a ...

journal_title：BMC infectious diseases

authors： Heinrich-Morrison K,McLellan S,McGinnes U,Carroll B,Watson K,Bass P,Worth LJ,Cheng AC

更新日期：2015-02-06 00:00:00

abstract：BACKGROUND:Penicillium marneffei disseminates hematogenously and can infect most organs, though infection leading to osteolysis is extremely rare. We describe the clinical and laboratory features, management, and outcomes of patients with penicilliosis marneffei (PSM) with osteolytic lesions. METHODS:This retrospectiv...

journal_title：BMC infectious diseases

authors： Qiu Y,Zhang J,Liu G,Zhong X,Deng J,He Z,Jing B

更新日期：2015-02-06 00:00:00

abstract：BACKGROUND:HIV-uninfected infants born to HIV-infected mothers (HIV-exposed uninfected, HEU) have been described to have immune alterations as compared to unexposed infants. This study sought to characterize T-cell populations after birth in HEU infants and unexposed infants living in a semirural area in southern Mozam...

journal_title：BMC infectious diseases

authors： de Deus N,Moraleda C,Serna-Bolea C,Renom M,Menendez C,Naniche D

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:In Ethiopia a tiebreaker algorithm using 3 rapid diagnostic tests (RDTs) in series is used to diagnose HIV. Discordant results between the first 2 RDTs are resolved by a third 'tiebreaker' RDT. Médecins Sans Frontières uses an alternate serial algorithm of 2 RDTs followed by a confirmation test for all doubl...

journal_title：BMC infectious diseases

authors： Shanks L,Siddiqui MR,Kliescikova J,Pearce N,Ariti C,Muluneh L,Pirou E,Ritmeijer K,Masiga J,Abebe A

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:After the onset of HAART, some HIV-infected individuals under treatment present a exacerbated inflammation in response to a latent or a previously treated opportunistic pathogen termed immune reconstitution inflammatory syndrome (IRIS). Few reports of tegumentary leishmaniasis have been described in associat...

journal_title：BMC infectious diseases

authors： Gois L,Badaró R,Schooley R,Grassi MF

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:Azithromycin has been widely used for Mycoplasma genitalium treatment internationally. However, the eradication efficacy has substantially declined recent decade. In Russia, josamycin (another macrolide) is the recommended first-line treatment for M. genitalium infections, however, no data regarding treatmen...

journal_title：BMC infectious diseases

authors： Guschin A,Ryzhikh P,Rumyantseva T,Gomberg M,Unemo M

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:For a long time, the role of CD8(+) T cells in blood-stage malaria was not considered important because erythrocytes do not express major histocompatibility complex (MHC) class I proteins. While recent evidences suggest that CD8(+) T cells may play an important role during the erythrocytic phase of infection...

journal_title：BMC infectious diseases

authors： Hojo-Souza NS,Pereira DB,Passos LS,Gazzinelli-Guimarães PH,Cardoso MS,Tada MS,Zanini GM,Bartholomeu DC,Fujiwara RT,Bueno LL

更新日期：2015-01-31 00:00:00

abstract：BACKGROUND:The human major histocompatibility complex class I polypeptide-related sequence B (MICB) is a protein that modulates the NK and T cell activation through the NKG2D receptor and is related to several diseases including cancer. METHODS:The study investigated the prognostic role of soluble MICB (sMICB) protein...

journal_title：BMC infectious diseases

authors： Tong HV,Song le H,Hoan NX,Cuong BK,Sy BT,Son HA,Quyet D,Binh VQ,Kremsner PG,Bock CT,Velavan TP,Toan NL

更新日期：2015-01-23 00:00:00

abstract：BACKGROUND:Variations at DEPDC5 gene have been recently reported as genetic markers associated with hepatocellular carcinoma (HCC) progression in chronic HCV-infected patients. This study was conducted to assess the association of DEPDC5 variants with advanced liver cirrhosis and HCC development among chronic HCV-infec...

journal_title：BMC infectious diseases

authors： Al-Anazi MR,Matou-Nasri S,Abdo AA,Sanai FM,Khan MQ,Albenmousa A,Al-Ashgar HI,Khalaf NZ,Al-Ahdal MN,Al-Qahtani AA

更新日期：2014-12-31 00:00:00

abstract：BACKGROUND:The diagnostic accuracy of fine-needle aspiration (FNA) cytology for the diagnosis of tuberculous lymphadenitis (TBLN) is confounded by mimicking cytomorphologic disorders. The objective of this study was to determine whether supplementing FNA cytology with bacteriological methods improves the overall accura...

journal_title：BMC infectious diseases

authors： Abdissa K,Tadesse M,Bezabih M,Bekele A,Apers L,Rigouts L,Abebe G

更新日期：2014-12-31 00:00:00

abstract：BACKGROUND:The objective of this study was to describe the clinical and microbiological characteristics of bloodstream infections (BSIs) due to AmpC producing Enterobacteriaceae (AE) in a large centralized Canadian region over a 9-year period. METHODS:An active surveillance cohort design in Calgary, Canada. RESULTS:A...

journal_title：BMC infectious diseases

authors： Chaubey VP,Pitout JD,Dalton B,Gregson DB,Ross T,Laupland KB

更新日期：2014-12-14 00:00:00

abstract：BACKGROUND:Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case-control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative a...

journal_title：BMC infectious diseases

authors： Picot VS,Bénet T,Messaoudi M,Telles JN,Chou M,Eap T,Wang J,Shen K,Pape JW,Rouzier V,Awasthi S,Pandey N,Bavdekar A,Sanghvi S,Robinson A,Contamin B,Hoffmann J,Sylla M,Diallo S,Nymadawa P,Dash-Yandag B,Russomando G

更新日期：2014-12-10 00:00:00

abstract：BACKGROUND:Pulmonary nocardiosis frequently occurs in immunocompromised hosts and in some immunocompetent hosts with chronic lung disease; however, few reports have described pulmonary nocardiosis with nontuberculous mycobacterial lung infection. Here we report for the first time two cases of pulmonary nocardiosis caus...

journal_title：BMC infectious diseases

authors： Yagi K,Ishii M,Namkoong H,Asami T,Fujiwara H,Nishimura T,Saito F,Kimizuka Y,Asakura T,Suzuki S,Kamo T,Tasaka S,Gonoi T,Kamei K,Betsuyaku T,Hasegawa N

更新日期：2014-12-10 00:00:00

abstract：BACKGROUND:The urine lipoarabinomannan (LAM) strip test has been suggested as a new point-of-care test for active tuberculosis (TB) among human immunodeficiency virus (HIV) infected individuals. It has been questioned if infections with nontuberculous mycobacteria (NTM) affect assay specificity. We set forth to investi...

journal_title：BMC infectious diseases

authors： Qvist T,Johansen IS,Pressler T,Høiby N,Andersen AB,Katzenstein TL,Bjerrum S

更新日期：2014-12-04 00:00:00